What are some popular drugs that are not very well thought of on this sub?

On Chambers, it often feels like drugs are either worshipped and glorified or they're portrayed as devil's medicine that will ruin your life.<br><br>This sub gives me a chill and genuine space to understand other perspectives, but there are some drugs that I feel are thought of particularly poorly here.<br><br>What are they and how do you think they should be approached?