What do you think is the single most important philosophical question of our time?

Inspired by this post on r/relationships, I'm running a similar thread here. The post on r/relationships asks for the single most important relationship question of our time. I think a similar question could be asked here. So, what do *you* think is the single most important philosophical question of our time? Please keep your answer to just a single comment, and please make sure to stay on topic (i.e. don't answer with the question you wish was the most important).